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Results: 11
Antigen discrimination by T cells relies on size-constrained microvillar contact.
Edward Jenkins, Markus Körbel, Caitlin O'Brien-Ball, James McColl, Kevin Y Chen, Mateusz Kotowski, Jane Humphrey, Anna H Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F Lee, Simon J Davis, David Klenerman
Apr 17, 2023
T cells use finger-like protrusions called 'microvilli' to interrogate their targets, but why they do so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer of large molecules forming a...
T-Lymphocytes microvilli Receptors Antigen T-Cell Antigens Lymphocyte Activation Signal Transduction
Published by: Nature Communications
Addressing Sustainability of Sanitation Systems
Recently, a technical draft of the international standard ISO/DIS 30500 for non-sewered sanitation systems has been developed (publication expected for 2018). Its innovative feature is the inclusion of sustainable aspects. This...
IT Policy & Standardization Computer Science and Information Technology IT Policy and Standardization
Published by: IGI Global
Smart Technologies, Digital Competencies, and Workforce Development
A mixed methods case study of the Government of Canada provides a lens through which the skills development and training and development challenges confronting the public sector in an era of digitization and smart technologies...
Published by: IGI Global
Opportunities and Challenges of Using Mobile Applications for Workplace Health Promotion
Workplace health promotion (WHP) needs be adjusted to the new ways of working and improved in terms of participation rates. As mobile applications (apps) have proved to be effective in various health areas, it might also be a...
Published by: IGI Global
Lunar eclipses illuminate timing and climate impact of medieval volcanism.
Sébastien Guillet, Christophe Corona, Clive Oppenheimer, Franck Lavigne, Myriam Khodri, Francis Ludlow, Michael Sigl, Matthew Toohey, Paul S Atkins, Zhen Yang, Tomoko Muranaka, Nobuko Horikawa, Markus Stoffel
Apr 17, 2023
Explosive volcanism is a key contributor to climate variability on interannual to centennial timescales1. Understanding the far-field societal impacts of eruption-forced climatic changes requires firm event...
Published by: Nature
GA4GH Phenopackets
Markus S Ladewig, Julius O B Jacobsen, Alex H Wagner, Daniel Danis, Baha El Kassaby, Michael Gargano, Tudor Groza, Michael Baudis, Robin Steinhaus, Dominik Seelow, Nikolaos E Bechrakis, Christopher J Mungall, Paul N Schofield, Olivier Elemento, Lindsay Smith, Julie A McMurry, Monica Munoz-Torres, Melissa A Haendel, Peter N Robinson
Apr 12, 2023
The Global Alliance for Genomics and Health (GA4GH) is developing a suite of coordinated standards for genomics for healthcare. The Phenopacket is a new GA4GH standard for sharing disease and phenotype information that...
Genetic forms of primary progressive aphasia within the GENetic Frontotemporal dementia Initiative (GENFI) cohort
Kiran Samra, Amy M MacDougall, Arabella Bouzigues, Martina Bocchetta, David M Cash, Caroline V Greaves, Rhian S Convery, Chris Hardy, John C van Swieten, Harro Seelaar, Lize C Jiskoot, Fermin Moreno, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Chris R Butler, Alexander Gerhard, Simon Ducharme, Isabelle Le Ber, Isabel Santana, Florence Pasquier, Johannes Levin, Markus Otto, Sandro Sorbi, Jason D Warren, Jonathan D Rohrer, Lucy L Russell, Genetic Frontotemporal dementia Initiative (GENFI)
Apr 17, 2023
Structural MRI predicts clinical progression in presymptomatic genetic frontotemporal dementia
Martina Bocchetta, Emily G Todd, Arabella Bouzigues, David M Cash, Jennifer M Nicholas, Rhian S Convery, Lucy L Russell, David L Thomas, Ian B Malone, Juan Eugenio Iglesias, John C van Swieten, Lize C Jiskoot, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio Tagliavini, Alexandre de Mendonça, Isabel Santana, Chris R Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Markus Otto, Sandro Sorbi, Isabelle Le Ber, Florence Pasquier, Jonathan D Rohrer, Genetic Frontotemporal dementia Initiative (GENFI)
Apr 17, 2023